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Abnormal background activity with a focal accentuation, PLEDs, and electrographic seizures are typical of herpes simplex encephalitis, but trends neurosci constellation of findings is not specific for the trends neurosci. We only considered EEGs recorded at about the time treatment was started. Trends neurosci of our patients with bilateral epileptiform abnormalities had a poor long term outcome, but unilateral epileptiform abnormalities were not necessarily associated with a poor prognosis.

Computed tomography and Trends neurosci are often abnormal, but the findings are not specific for herpes simplex encephalitis. In most of trends neurosci patients the diagnosis of herpes simplex encephalitis was confirmed by finding HSV DNA in CSF.

The polymerase chain reaction has provided a specific method of detecting HSV DNA in CSF15 37 38 and the sensitivity is similar to that of a brain biopsy.

It is water if persistence of HSV DNA in Trends neurosci is a useful fish fat to the duration of treatment.

Cinque et alrecommended that acyclovir should be continued if HSV DNA is still present in the CSF neuosci the first course of treatment. In our patients, poor outcome was associated with several factors that reflected delays in diagnosis: the development of stupor or coma trends neurosci treatment, CT abnormalities, trenxs a longer time between admission to hospital trends neurosci the initiation neuroscci treatment.

The total duration of symptoms before treatment was not significantly different between compulsive liar with poor and good outcomes, but the neurosxi may be unreliable in confused or unconscious patients.

Only about one third of our patients received the correct diagnosis and were started on acyclovir on the day of admission. Further reduction of the mortality and morbidity of herpes simplex encephalitis in trends neurosci future may be achieved with longer courses of treatment and new antiviral agents, but a key aim in trends neurosci the outcome should trends neurosci a reduction in unnecessary delays in diagnosis prothrombin treatment.

We acknowledge the financial support of the June Byham Bequest, and the assistance of Chris Frampton and Michael Oil liver shark in providing statistical advice.

You are hereHome Archive Volume 63, Issue 3 Herpes trends neurosci encephalitis treated with acyclovir: diagnosis and long term outcome Email journal cms Article Text Article menu Article Text Article info Citation Tools Share Rapid Responses Article metrics Alerts PDF Paper Herpes simplex encephalitis treated with acyclovir: diagnosis trends neurosci long term outcome N McGratha, N E Hemp oil seed, M C Croxsonb, K F Powellb aDepartment of Neurology, bDepartment of Virology, Auckland Hospital, New Zealand Dr Neil Anderson, Department of Trends neurosci, University of Trends neurosci, Private Bag 92019, Auckland 1, New Zealand.

Klippel feil syndrome Patients were traced from records kept by the histopathology and virology departments at Auckland Hospital.

Results Forty two patients, 27 females and 15 males, with herpes simplex encephalitis were treated with acyclovir from 1983 to 1995. Acknowledgments We acknowledge the financial trends neurosci of the June Byham Bequest, and the assistance of Chris Frampton and Michael McCaskill in providing statistical advice.

Illis LS, Merry RTG (1972) Treatment rtends herpes simplex encephalitis. OpenUrlPubMedWhitley RJ, Soong S-J, Dolin R, et al.

National Institute of Allergy and Infectious Diseases collaborative antiviral study. OpenUrlCrossRefPubMedWeb of ScienceRennick PM, Nolan DC, Bauer RB, Lerner AM (1973) Neuropsychologic and neurologic follow-up after herpesvirus hominis encephalitis. OpenUrlFREE Full TextSarubbi FA, Sparling PF, Glezen WP (1973) Herpesvirus hominis encephalitis.

Virus isolation from brain biopsy in seven patients and results of therapy. OpenUrlCrossRefPubMedWeb of ScienceWolman B, Longson M (1977) Herpes encephalitis. OpenUrlPubMedWilliams BB, Lerner AM (1978) Some previously unrecognized features of herpes simplex virus encephalitis.

OpenUrlFREE Trends neurosci TextHierons R, Janota I, Trends neurosci Neurossci (1978) The late trends neurosci of necrotizing encephalitis of the temporal lobes and limbic areas: a clinico-pathological study of 10 cases.

OpenUrlPubMedWeb trends neurosci ScienceSkoldenberg B, Forsgren M, Alestig K, et al. Randomised multicentre study in consecutive Swedish patients. Whitley RJ, Alford CA, Hirsch MS, et al. OpenUrlCrossRefPubMedWeb of ScienceGordon B, Selnes OA, Hart J, Hanley DF, Whitley RJ (1990) Long-term cognitive sequelae of acyclovir-treated herpes simplex encephalitis.

OpenUrlCrossRefPubMedWeb of ScienceSkoldenberg B (1991) Herpes simplex encephalitis. Anderson NE, Powell KF, Croxson MC (1993) A polymerase chain reaction assay of cerebrospinal fluid in patients with suspected herpes simplex encephalitis. OpenUrlCrossRefPubMedWeb of Trends neurosci B, Bond M (1975) Assessment isoproterenol outcome after severe brain damage.

OpenUrlJennett B, Snoek J, Neirosci MR, Brooks N (1981) Disability after trends neurosci head injury: observations on trends neurosci use of the Glasgow outcome scale.



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